6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist

J Med Chem. 1997 Oct 24;40(22):3494-6. doi: 10.1021/jm970424c.
No abstract available

MeSH terms

  • Aminopyridines / chemistry
  • Aminopyridines / pharmacokinetics
  • Aminopyridines / pharmacology*
  • Animals
  • Blood-Brain Barrier*
  • Cell Line
  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Indoles / chemistry
  • Indoles / pharmacokinetics
  • Indoles / pharmacology*
  • Molecular Structure
  • Rats
  • Receptor, Serotonin, 5-HT2C
  • Receptors, Serotonin / drug effects*
  • Serotonin Antagonists / chemistry
  • Serotonin Antagonists / pharmacokinetics
  • Serotonin Antagonists / pharmacology*

Substances

  • 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline
  • Aminopyridines
  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • Indoles
  • Receptor, Serotonin, 5-HT2C
  • Receptors, Serotonin
  • Serotonin Antagonists